Anisomelic acid (AA) (Fig. S1†) is a diterpenoid compound isolated from the medicinal plant Anisomeles malabarica 7 , which we have previously shown to be cytotoxic to oral and

42, 2015. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

Synthesis and Evaluation of Anisomelic acid-like Compounds for the Treatment of HPV-Mediated Carcinomas Rajendran Senthilkumar , Yury Brusentsev , +4 authors J. Eriksson Scientific Reports Anisomelic acid (AA), one of the major compounds in Anisomeles malabarica, was tested for its cytotoxicity and apoptosis-inducing potential in breast and cervical cancer cells. The MTT assay for cell viability indicated that AA is cytotoxic to all of the four cell lines tested in a dose- and duration-dependent manner. Anisomelic acid was present in the crude n-hexane and chloroform extracts as seen in the RP-HPLC, and it reveals that AA is one of the major compounds in this plant. Since the trends produced by the extracts [ 11 ] and the pure compound AA were comparable, we are led to conclude that AA is the principal factor in the extracts, or one of the factors responsible for the observed cytotoxic effect. WO2014033366A1 PCT/FI2013/050828 FI2013050828W WO2014033366A1 WO 2014033366 A1 WO2014033366 A1 WO 2014033366A1 FI 2013050828 W FI2013050828 W FI 2013050828W WO 2014033366 A1 WO201 Our recent studies have demonstrated that a plant-derived diterpenoid compound, anisomelic acid (AA), induces apoptosis in cervical cancer cells. In this work, we describe the development of a folic acid (FA)-targeted AA delivery system using chitosan-coated rod-shaped mesoporous silica particles (Chitosan-NR-MSP).

Anisomelic acid, one of the major compounds in Anisomeles malabarica (L.) R. Br., is a cembrane-type diterpenoid, which can be synthesized chemically . Anisomelic acid has also been previously isolated from A. malabarica and A. indica and it has been shown to be cytotoxic to KB cells [5, 6].

Activities (22) Anthelmintic AntiHIV EC50=2.0 ug/ml Kashiwada, Y Anisomelic acid (AA) is a macrocyclic cembranolide compound extracted from Anisomeles herbal species. Recently, we have shown that AA possesses both anticancer and antiviral activity.

Analysis of the Cytotoxic Potential of Anisomelic Acid Isolated from Anisomeles malabarica. Scientia Pharmaceutica, 2013. Mohammad Akbarsha. Preethy Paul. Ali …

Here, we describe the molecular interactions of AA with two serum proteins, human serum albumin (HSA) and bovine serum albumin (BSA Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles mal - abarica . Recently, we have studied the mode of action of AA-mediated apoptosis Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands.

doi: 10.1038/s41598-019-56410-1. Senthilkumar R, Brusentsev Y, Paul P, Marimuthu P, Cheng F, Eklund PC & Eriksson JE (2019).
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A strong acid is one that is completely dissociated or ionized in an aqueous solution. It is a chemical species with a high capac Teichoic acid is a structure found exclusively in gram-positive bacterial cell walls. This acid is formed through the joining of either glycerol phosphate Teichoic acid is a structure found exclusively in gram-positive bacterial cell walls.

Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect By Rajendran Senthilkumar, Didem Şen Karaman, Preethy Paul, Emma M. Björk, Magnus Odén, John E. Eriksson and Jessica M. Rosenholm petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4].
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In a pioneering study, we showed that a naturally occurring compound (anisomelic acid), as well as synthetic derivatives that we have developed based on this compound, effectively degrade the HPV E6 and E7 oncoproteins, i.e., the carcinogenic proteins in the virus that are known to play a key role in promoting the devel opment of HVP-positive cancers, says cell biology professor John Eriksson

MeSH® ID, D004224. External Links. PubChem By a further functionalization of glass slides with hyaluronic acid it was possible compound anisomelic acid using chitosan-coated porous silica nanorods for 42, 2015. Targeted delivery of a novel anticancer compound anisomelic acid using chitosan-coated porous silica nanorods for enhancing the apoptotic effect.

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Synthesis and evaluation of anisomelic acid like compounds for the treatment of HPV-mediated carcinomas Annual Congress on Medicinal Chemistry, Pharmacology and toxicology July 30 - 31 , 2018 Amsterdam , Netherlands. Rajendran Senthilkumar, Yury Brusentsev, Preethy Paul, Fang Cheng, Maria Sippola-Thiele, Patrik Eklund and John E Eriksson

Mohammad Akbarsha. Preethy Paul. Ali Alshatwi.

Acid reflux, often referred to as heartburn, is an uncomfortable burning sensation that might occur after a big meal as a result of stomach acid backing up. This article explores acid reflux, what causes it, and how to prevent and treat thi

What does AA stand for in Pharmacy? Get the top AA abbreviation related to Pharmacy. Anisomelic acid | C20H26O4 | CID 5358705 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. 2019-12-30 · Our earlier research on the cembranoid, anisomelic acid (AA) showed that, AA has the potential to induce apoptosis in HPV cells by the depletion of E6 and E7 oncoproteins. The present study describes the structure-activity relationship and the evaluation of synthetic AA like compounds, i.e simplified cembranoid-like structures, as HPV inhibitors against some papilloma cell lines. Anisomelic acid (AA) is one of the principle bioactive compounds isolated from the plant Anisomeles malabarica. Recently, we have studied the mode of action of AA-mediated apoptosis, indicating 1987-01-01 · Anisomelic acid is found in the South Indian medicinal plant Amsomeles malabauta R.Br.l, whereas the lobohedleolides are constituents of the soft coral Lobophytum hedlejt Whitelegge, which inhabits a region of Okinawa.2 Lobohedleolide inhibits growth of Hella cells in vitro at 5 ug/mL.2 No specific biological activity has been reported for the other members of the triad.

Biochemical Pharmacology. 89:171–184. petroleum ether extract of plant contains a triterpenic acid known as betulinic acid [3] while the hexane extract consists of β-sitosterol and diterpenoids (ovatodiolide and anisomelic acid) [4]. The aerial parts contain anisomelolide, malabaric acid, 2-acetoxymalabaric acid, anisomelyl acetate, anisomelol and … Pharmacy AA abbreviation meaning defined here.